Relationship between serum dehydroepiandrosterone and the level of blood uric acid in non-obese males

Objective To investigate relationship between serum dehydroepiandrosterone levels and serum uric acid (SUA) in non-obese males so as to provide theoretical basis for the intervention of risk factors of hyperuricemia.Methods The objects of this study were 730 cases of non-obese men in Chengyang District People's Hospital of Qingdao in 2012, aged 35-75 years old (excluding diabetes, hypertension, renal failure, etc). According to the SUA levels, the following 4 groups were set up:group A (106 cases, SUA < 330 μmol/L), group B (173 cases, 330 μmol/L ≤ SUA < 360 μmol/L), group C (103 cases, 360 μmol/L ≤ SUA < 420 μmol/L), and group D (348 cases, SUA ≥ 420 μmol/L). A questionnaire survey was conducted on the subjects. The history of smoking and drinking was asked. Diastolic blood pressure (DBP), systolic blood pressure (SBP), height, weight and waist circumference (WC) were measured. Early morning fasting venous blood was collected, and fasting blood glucose (FBG), SUA, serum lipid and serum DHEA were determined. SPSS16.0 statistical software was used for statistical analysis.Results The DHEA change trend was as follows:group A (13.5±1.6) μmol/L > group B (9.2±1.4) μmol/L > group C (5.1±1.3) μmol/L > group D (1.9±1.2) μmol/L, with the difference being statistically significant among the groups (P<0.05 or P<0.01). Using the SUA as the dependent variable, and age, DHEA, BMI, WC, SBP and TG as variables, the multivariate linear regression revealed DHEA, BMI, TG and SBP entered the regression equation, and the difference was statistically significant (t=-2.125, 8.261, 6.199 and 5.678, P<0.05 or P<0.01).Conclusions In non-obese males, there was a correlation between SUA and serum DHEA. Serum DHEA decreased gradually, and the level of SUA increased. Simultaneously, decreased DHEA may be the risk factor of hyperuricemia. Therefore, the level of SUA in non-obese men is not only concerned with the conventional risk factors, but also should pay attention to DHEA and other non-conventional risk factors, which is beneficial to targeted therapy.