Clinical study of bone mineral density of maintenance hemodialysis patients with serious secondary hyperparathyroidism by dual energy X-ray absorptiometry

Objective To study the bone mineral density (BMD) of maintenance hemodialysis (MHD) patients with serious secondary hyperparathyroidism.Methods The enrolled consisted of 55 MHD subjects in our hospital, including 33 males and 22 females. The gender, age, height, weight, dialysis duration, and biochemical indicators were investigated, and the BMD was tested by dual energy X-ray absorptiometry (DXA).Results Based on the tests of DXA, the T score of lumbar spine was -1.73±1.29, osteoporosis and osteopenia accounted for 23.64% and 50.91%, respectively. The associated factors of BMD included iPTH (r=-0.506, P=0.000), ALP (r=-0.336, P=0.012), and serum albumin (r=0.268, P=0.048). Trend test showed BMD was gradually reduced from L1 to L4 (F for trend=11.328, and P for trend=0.001). The T score of left femoral neck was -1.72±1.21, and osteoporosis and osteopenia accounted for 25.45% and 49.09% respectively, respectively. The associated factors of BMD included iPTH (r=-0.346, P=0.010), ALP (r=-0.402, P=0.002), and serum albumin (r=0.441, P=0.001). Paired chi-square test revealed similar diagnosis of BMD between lumbar spine and femoral neck.Conclusions In our study, the prevalence of osteoporosis and osteopenia was high. The diagnosis results of BMD are similar between lumbar spine and femoral neck. The associated factors of BMD include iPTH, ALP and serum albumin.