Diagnostic value of ET-1 and UA in early kidney injury of pregnancy-induced hypertension

Objective To observe the diagnostic value of endothelin-1 (ET-1) and uric acid (UA) in early kidney injury of pregnancy-induced hypertension (PIH).Methods From January 2010 to January 2016, 303 PIH patients were enrolled to the Obstetrics and Gynecology Department of Wuhan Medical & Healthcare Center for Women and Children as PIH group, and 100 normal pregnant women served as control group. PIH group was assigned into mild with 124 cases, moderate 97 cases and severe 82 cases according to the severity of PIH. Then PIH patients were also divided into two groups:kidney injury group (n=112) and normal group (n=191) based on the kidney function. The relationship between the levels ET-1, UA with the severity of PIH and kidney injury was observed. The diagnostic value was verified on the risk factors by receiver operating characteristic (ROC) curve.Results The levels of ET-1 and UA in PIH group were significantly higher than in the control group (P<0.01). The levels of ET-1 and UA were related to the severity of PIH. Univariate analysis showed there was significant difference between kidney injury group and normal group in ET-1 (t=9.461, P<0.01), UA (t=10.618, P<0.01), systolic blood pressure (t=11.376, P<0.05), diastolic blood pressure (t=8.642, P<0.01), SCr (t=6.986, P=0.011), Ccr (t=5.874, P=0.013), Hcy (t=6.618, P<0.01), and Cys C (t=7.014, P=0.010); ROC curve analysis revealed that the optimal cutoff of ET-1 was 81.35 ng/L (AUC=0.814, sensitivity 0.772, specificity 0.806); and the optimal cutoff of UA was 480.68 μmol/L (AUC=0.786, sensitivity 0.822, specificity 0.786).Conclusions It is proven that the ET-1 combined with UA had an important value in diagnosing PIH patients with early kidney injury.