Abstract: Renal fibrosis is a common pathological manifestation of chronic kidney disease （CKD）. Since the process of renal drug delivery is rather complex, there is currently no effective remedy for reversing renal fibrosis （RF）. Nanotechnology has been widely applied in the field of medicine and its targeting applications bring new hopes for managing RF. Currently numerous studies are aimed at developing delivery systems of targeting specific renal regions, cells or proteins. This review summarized the current diagnoses of RF, different targeting strategies and potential nano-preparations of plant extracts for treating RF.