不同降糖药与2型糖尿病患者急性肾损伤发生关系的研究进展

Research advances on the relationship between different hypoglycemic agents and acute kidney injury in type 2 diabetic patients

摘要: 急性肾损伤（acute kidney injury，AKI）发病率逐年升高，可导致患者住院时间延长甚至增加其病死率。糖尿病是AKI的独立危险因素，糖尿病患者往往使用降糖药物来控制血糖。研究表明，不同种类的降糖药对AKI的发生可能有一定的影响，包括二甲双胍、钠-葡萄糖协同转运蛋白2抑制剂、肠促胰岛素类似物（胰高血糖素样肽-1受体激动剂、二肽基肽酶4抑制剂）等。本文就以上问题针对相关药物与AKI发生的关系进行讨论。

Abstract: A rising incidence of acute kidney injury (AKI) may lead to longer hospitalization stays and even greater mortality. Diabetes is an independent risk factor for AKI and using hypoglycemic agents has been a fundamental glycemic control in diabetics. Studies have shown that different types of hypoglycemic agents may have an effect on the occurrence of AKI, including metformin, SGLT2 inhibitors and entero-insulin analogues (GLP-1 receptor agonists, DPP4 inhibitors). This review focused upon the relationship between related drugs and AKI.