Abstract: Macrophages are important cells involved in inflammatory damage in chronic kidney disease. The characteristic alteration of macrophage function due to changes in the local microenvironment is referred to as macrophage reprogramming. In recent years, altered macrophage reprogramming affecting inflammatory tissue injury has received increasing attention. This article reviews advances in the understanding of macrophage metabolic reprogramming pathways and studies that influence macrophage polarization and impact inflammatory injury in chronic kidney disease.