Abstract: Objective To retrospectively analyze the causes for restriction of single-center highflow autogenous arteriovenous fistula over the last two years and examine the efficacy of modified restriction. Methods From August 2018 to September 2020, clinical demographics, primary disease, dialysis age and blood flow before and after restriction were retrospectively analyzed for 23 patients with high flow autogenous arteriovenous fistula undergong flow restriction surgery. Results Among them, there were extremity swelling at fistula side (n=13), aneurysms (n=8) and neck swelling (n=2).Blood flow of brachial artery was (2292.85±587.76) mL/min preoperatively, (817.33±255.08) mL/min postoperatively and (843.33±212.85) mL/min at Month 6 post-operation.Paired t-test indicated that blood flow of brachial artery pre/post-operation and Month 6 post-operation was significantly different (P<0.05). As for postoperatively and Month 6 post-operation, there was no significant inter-group difference (P=0.195). Conclusion Modified utogenous arteriovenous fistula restriction is simple, safe and effective in the treatment of high flow internal fistula.It is worthy of wider clinical popularization.