Abstract: Objective To systematically review and synthesize the life experience of hemodialysis patients and provide reference for improving the quality of patient life and boosting the quality of nursing service.Methods The databases of Cochrane Library,PubMed,Embase,CBM,CNKI,VIP and WanFang were searched for qualitative researches on the life experience of hemodialysis patients from inception to July 2020.Results A total of 17 studies were included,34 results extracted,7 categories summarized and 3 integration results synthesized.Integration result I:Positive and negative emotional coexistence in patients;Integration result II:Hemodialysis patients faced challenges in exercise,diet and social intercourse;Integration result III:Patients were eager to gain supports from the outside world,enable positive changes,establish a future outlook and cherish the present.Conclusion Healthcare practitioners should pay due attention to life situation,emotional experience and actual needs,intensify targeted psychological interventions,provide necessary assistance and elevate the quality of life of hemodialysis patients.