Abstract: Objective To evaluate the therapeutic efficacy of liver failure patients with blood purification technology under different modes. Methods All patients of liver failure received blood purification,including separate plasma exchange(PE),PE+bilirubin adsorption and PE+double plasma molecular adsorption system(DPMAS). Clinical data were collected for selected candidates. The counts of total bilirubin,direct bilirubin,liver function,kidney function,hemoglobin and platelets before and after treatment were recorded. And the levels of prothrombin time(PT),activated partial thromboplastin time(APTT),international normalized ratio(INR) score changes of model for end-stage liver disease(MELD) and efficacies of three groups were also compared. Moreover,the effects of human plasma and albumin dosage were evaluated. Results The clinical data of each group before and after treatment were compared. In PE+DPMAS group,total bilirubin,direct bilirubin,aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,total protein,lactate dehydrogenase,urea nitrogen,creatinine,hemoglobin and MELD scores declined markedly while PT,APTT and INR spiked with statistical significance(P<0.05). In PE+bilirubin adsorption group,total bilirubin and direct bilirubin declined markedly and albumin became elevated(P<0.05). In PE group,total bilirubin and direct bilirubin showed a declining trend. When three groups were compared with each other,total bilirubin,direct bilirubin,aspartate aminotransferase,aspartate aminotransferase,alkaline phosphatase,APPT and MELD scores decreased markedly in PE+DPMAS group and there was statistical significance(P<0.05). The amount of albumin supplementation in PE+bilirubin adsorption group was negatively correlated with lower bilirubin(r=-0.34,P=0.02). And there was statistical significance. Conclusion Three blood purification modes may improve liver function in different degrees. In PE+DPMAS group,the efficiency of lowering bilirubin was higher than that in PE or PE+bilirubin adsorption group. The more albumin supplemented in PE+bilirubin adsorption group during treatment,the greater reduction in bilirubin.