Abstract: With the characteristics of high incidence,high mortality,high health-economic cost and social burden,acute kidney injury(AKI) has become a worldwide public health problem.Currently there is no established pharmacotherapy for AKI.Emerging studies have proposed that gut-kidney axis crosstalk may play an important role in the occurrence and development of AKI and its distal non-renal organ injury/dysfunction.And it is expected to become a new promising target for intervention.This review summarized the bidirectional role of intestinal-renal axis in AKI,including secondary intestinal barrier injury,gut-derived immune response,inflammation disorders,intestinal-related host immunomodulation and homeostasis of gut microbiome.The possible mechanisms were explore for intervening AKI based upon intestinal-renal axis from the perspective of achieving multi-system balance by adjusting intestinal homeostasis.The latest research advances were discussed for providing new ideas and methods for improving the prognosis of AKI.