双特异性磷酸酶在肾脏疾病中的研究进展

Research advances of dual-specificity phosphatases in kidney disease

摘要: 双特异性磷酸酶（dual-specificity phosphatases，DUSPs）是酪氨酸磷酸酶（protein tyrosine phosphatases，PTPs）家族中的一员，具有使磷酸化的底物蛋白丝/苏氨酸以及酪氨酸脱磷酸化的双重作用。近年来，随着对DUSPs家族成员的深入研究表明，DUSPs能够参与机体多种生理及病理活动。而与丝裂原活化蛋白激酶（mitogen-activated protein kinase，MAPK）途径相关的DUSPs在多种肾脏疾病中发挥着重要调控作用。本文在深入理解DUSPs在肾脏病领域中研究进展的基础上，就DUSPs的一般特性及其在肾脏病中的研究现状做一综述。

Abstract: Belonging to the family of protein tyrosine phosphatases,DUSPs(dual-specificity phosphatases)can dephosphorylate both serine/threonine and tyrosine residues concurrently.In recent years,with the in-depth study of DUSPs,they have been implicated as major participants in various physiological and pathological activities.And DUSPs related to MAPK(mitogen-activated protein kinase)play a vital regulatory role in a variety of kidney diseases.This review summarized the general characteristics and current researches of DUSPs in nephrology.