CC趋化因子受体2/单核细胞趋化蛋白1与肾脏疾病的研究进展
Research advances of CCR2/MCP-1 and kidney diseases
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摘要: CC趋化因子受体2（CC chemokine receptor，CCR2）是单核细胞趋化蛋白-1（monocyte chemoattractant protein，MCP-1）的主要受体，可与MCP-1发生特异性结合将信号转入细胞内，趋化并激活单核/巨噬细胞，促进炎症的发生发展。研究表明，CCR2/MCP-1参与了多种肾脏疾病的发展进程，本文就近年来CCR2/MCP-1与肾病研究进展做一综述。Abstract: As a major receptor of monocyte chemotactic protein-1(MCP-1),CC chemokine receptor 2(CCR2) can specifically conjugate to MCP-1,transfer signals into cytoplasm,mediate the chemotaxis and activation of monocytes and macrophages and promote the occurrence and development of inflammation.Previous studies have shown that CCR2/MCP-1 were involved in the development of many kidney diseases.This review summarized the recent research advances of CCR2/MCP-1 and kidney disease.
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