Abstract: Objective To explore the clinical effect of alpha-lipoic acid plus high flux hemodialysis on diabetics with peripheral neuropathy.Methods A total of 60 patients with diabetic hemodialysis and peripheral neuropathy were selected from 2016 to 2019.They were randomly divided into control and observation groups.Control group received routine hemodialysis 3 times a week,4 hours each time and took alpha-lipoic acid capsule,1 capsule each time,3 times daily;observation group was offered high flux hemodialysis treatment 3 times a week,4 hours each time and also took alpha-lipoic acid capsule(same as control group).Both groups were for 12 weeks.The clinical symptoms(limb pain,numbness & restless leg syndrome),serum levels of oxidative stress indexmalondialdehyde(MDA) & advanced protein oxidation products(AOPP) and of serum parathyroid hormone(iPTH),β2-microglobulin and peripheral nerves,sensory conduction velocity(median nerve,common peroneal nerve & tibial nerve) were compared between two groups before and after 12 weeks.Results After 12 weeks of treatment,clinical symptoms,oxidative stress parameters and nerve sensory conduction velocity markedly improved in both groups(P<0.05) and the improvement was more obvious in observation group than that in control group(P<0.05).After dialysis,the levels of parathyroid hormone and β2-microglobulin were significantly lower in observation group than those in control group(P<0.05).Conclusions Alpha-lipoic acid plus high flux hemodialysis can improve peripheral neuropathy in diabetic hemodialysis patients.