育龄期女性终末期肾病血液透析患者性激素水平检测及其与血清25-羟维生素D关系的探讨

    Detection of sex hormone level in hemodialysis female patients with end-stage renal disease of childbearing age and its relationship with serum 25 hydroxyvitamin D

      摘要
    • 摘要: 目的 探讨育龄期女性终末期肾病血液透析患者性激素水平与血清25-羟维生素D25（OH）D的关系探讨。方法 选取2016年5月至2019年11月西电集团医院收治的91例育龄期女性终末期肾病血液透析患者作为透析组，另选取87例同期体检健康的育龄期女性作为健康组，均行性激素黄体生成素（luteinizing hormone，LH）、卵泡刺激素（follicle stimulating hormone，FSH）、催乳素（prolactin，PRL）、雌二醇（estradiol，E2）、孕酮（progesterone，P）、睾酮（testosterone，T）水平及血清25（OH）D水平检测。对比2组性激素各项指标及血清25（OH）D水平，并采用Pearson相关性分析法分析透析组LH、FSH、PRL、E2、P、T与25（OH）D水平的关系。结果 透析组血清LH、FSH、PRL水平均高于健康组，透析组E2、P、T水平均低于健康组，差异均有统计学意义（P<0.05）；透析组血清25（OH）D水平明显低于健康组（P<0.05），透析组维生素D缺乏或不足总占比为83.52%，明显高于健康组的12.64%（P<0.05）；透析组血清LH、FSH水平与25（OH）D水平呈显著负相关性（P<0.05），血清E2水平与25（OH）D水平呈显著正相关性（P<0.05），而血清PRL、P、T水平与25（OH）D水平无明显相关性（P>0.05）。结论 育龄期终末期肾病血液透析女性患者存在性激素水平紊乱及维生素D缺乏或不足现象，且LH、FSH、E2水平与血清25（OH）D水平具有一定相关性。

       

      Abstract: Objective To explore the relationship between sex hormone levels and serum 25 hydroxyvitamin D25(OH) Din female patients of childbearing age with end-stage renal disease on hemodialysis(HD).Methods From May 2016 to November 2019,91 female HD patients of childbearing age with end-stage renal disease(dialysis group) and 87 healthy controls(healthy group) were selected during the same period.And the levels of sex hormones including luteinizing hormone(LH),follicle stimulating hormone(FSH),prolactin(PRL),estradiol(E2),progesterone(P),testosterone(T) and serum 25(OH) D were detected.Sex hormone parameters and serum level of 25(OH) D were compared between two groups and the relationship between the levels of LH,FSH,PRL,E2,P,T and 25(OH) D in dialysis group was analyzed by Pearson's correlation.Results The serum levels of LH,FSH and PRL were higher in dialysis group than those in healthy group.And the levels of E2,P and T were lower in dialysis group than those in healthy group and the differences were significant(P<0.05).The serum level of 25(OH) D was significantly lower in dialysis group than that in healthy group(P<0.05).The total ratio of vitamin D deficiency or insufficiency was 83.52% in dialysis group and it was significantly higher than that of healthy group(12.64%) (P<0.05).Significant negative correlations existed between serum LH/FSH and 25(OH) D(P<0.05) and a significant positive correlation existed between serum E2 and 25(OH) D(P<0.05).However,no significant correlation existed between serum levels of PRL,P,T and 25(OH) D(P>0.05).Conclusion Female HD patients of childbearing age with end-stage renal disease have sex hormone disorder and vitamin D deficiency or insufficiency.And the levels of LH,FSH and E2 are correlated with serum level of 25(OH) D.

       

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