Abstract: Objective To evaluate the impact of soy protein on chronic kidney disease(CKD)and provide references for the importance of adding soy protein in a CKD diet.Methods The databases of PubMed,Embase,Cochrane Library,National Knowledge Infrastructure of China,Chinese Journal of Science & Technology,WanFang Data Chinese Edition and China Biomedicine(CBM)were searched since their inceptions until June 30,2020.After literature screening,quality evaluation was performed and Rev Man5.3 software utilized for Meta-analysis.Results Nine articles involving a total of 429 subjects from 5 countries were included.Meta-analysis indicated that soy protein diet could lower the levels of serum creatinine(Scr)SMD=-0.33,95%CI(-0.54,-0.13),P=0.001,blood urea nitrogen(BUN)SMD=-0.45,95%CI(-0.89,-0.01),P=0.05 and low-density lipoprotein-cholesterol(LDL-C)SMD=-0.79,95%CI(-1.10,-0.47),P<0.001 in CKD patients.The levels decreased markedly as compared with control group and there were statistical differences(P<0.05).And the effects on glomerular filtration rate(GFR),proteinuria and serum phosphorus were not significantly different from those of control group.Conclusion Soy protein may reduce the levels of Scr,BUN and LDL-C in CKD patients.Based upon a low quality of literature reports and a protracted disease course of CKD,some conclusions should be further verified by larger studies with longer treatment courses.