Abstract: Objective To explore the association between mean platelet volume(MPV)and bone mineral density(BMD)in type 2 diabetics with CKD stage 1-2.Methods General demographic profiles and clinical data(urine microalbumin/urinary creatinine,blood routine,glycated hemoglobin,serum levels of albumin,alkaline phosphatase,creatinine,urea nitrogen,uric acid,lipids,calcium,magnesium,phosphorus,body muscle content,body fat content,BMD in lumbar vertebra 1-4,BMD in femur and BMD in Wards triangular zone of femur)were collected for retrospective analysis.A total of 117 type 2 diabetics with CKD stage 1-2 were recruited and divided into the groups of normal MPV level(N-MPV,n=70)and high MPV level(H-MPV,n=47).Clinical data,laboratory parameters and BMD were compared between two groups.Correlation and multiple linear regression analyses were conducted.Results As compared with H-MPV group,platelet count(t=3.477,P<0.001),blood uric acid(t=2.213,P=0.029)and lumbar_1-4 BMD(t=2.118,P=0.037)were significantly higher in N-MPV group.Correlation study revealed that MPV was negatively correlated with platelet count(r=-0.249,P=0.014),serum uric acid(r=-0.248,P=0.014),lumbar_1-4 BMD(r=-0.348,P<0.01),femoral BMD(r=-0.267,P=0.008)and BMD in Wards triangular zone of femur(r=-0.236,P=0.020).Serum uric acid was positively correlated with lumbar_1-4 BMD(r=0.238,P=0.019).Multivariate regression analysis revealed that high MPV was an independent risk factor for lower lumbar_1-4 BMD(β=-0.064,P=0.002).Conclusion Elevated MPV is closely correlated with lumbar_1-4 BMD value in type 2 diabetics with CKD stage 1-2.