血清成纤维细胞生长因子21、信号肽-CUB-表皮生长因子结构域包含蛋白1对维持性血液透析患者主要不良心血管事件发生预测价值

    Predictive values of serum FGF21 and SCUBE-1 in predicting major adverse cardiovascular events in maintenance hemodialysis patients

      摘要
    • 摘要: 目的 探究血清成纤维细胞生长因子21（fibroblast growth factor 21,FGF21）、信号肽-CUB-表皮生长因子结构域包含蛋白1（signal peptide-CUB-EGF-like domain-containing protein,SCUBE-1）水平对维持性血液透析（maintenance hemodialysis,MHD）患者发生主要不良心血管事件（major adverse cardiovascular events,MACE）发生的预测价值。方法 选取2020年2月1日至2023年2月28日于海安市人民医院入院治疗的164例MHD患者作为观察组,对患者进行1年的随访,依据患者是否发生MACE将其分为发生组（117例）和未发生组（47例）；选取同期入院体检的164名健康者作为对照组。采用酶联免疫活性吸附法检测血清FGF21、SCUBE-1水平；采用多因素Logistic回归分析MHD患者发生MACE的影响因素；受试者工作特征曲线分析血清FGF21、SCUBE-1对MHD患者发生MACE的预测价值。结果 观察组患者的血清FGF21（39.67 ± 5.54）ng/L比（30.33 ± 3.21）ng/L、SCUBE-1水平（33.28 ± 4.41）μg/L比（25.19 ± 2.68）μg/L显著高于对照组（P<0.05）；发生组血清FGF21（44.94 ± 4.52） ng/L比（37.55 ± 4.43） ng/L、SCUBE-1（36.86 ± 3.87） μg/L比（31.84 ± 3.74）μg/L、糖尿病史占比（80.85%比25.64%）、低密度脂蛋白胆固醇水平（3.26 ± 0.36）mmol/L比（2.89 ± 0.30）mmol/L均显著高于未发生组（P<0.05）；FGF21、SCUBE-1是MHD患者发生MACE的影响因素（P<0.05）；血清FGF21、SCUBE-1预测MACE发生的曲线下面积为0.881、0.823,二者联合预测MACE发生的曲线下面积为0.926,二者联合优于血清FGF21、SCUBE-1各自单独预测（Z二者联合-FGF21=2.024、Z二者联合-SCUBE-1=3.082,P=0.043、0.002）。结论 血清FGF21水平、SCUBE-1水平显著升高,是MHD患者发生MACE的危险因素,二者联合对MHD患者发生MACE具有较高的预测价值。

       

      Abstract: Objective To investigate the predictive values of serum fibroblast growth factor 21（FGF21） and signal peptide, CUB and EGF-like domain-containing protein 1（SCUBE-1） in predicting major adverse cardiovascular events（MACEs） in maintenance hemodialysis（MHD） patients. Methods A total of 164 MHD patients admitted to our hospital from February 1, 2020 to February 28, 2023 were regarded as the observation group. The patients were followed up for 1 year and separated into an occurrence group （117 cases） and a non-occurrence group （47 cases） based on whether they had MACEs. A total of 164 healthy individuals who underwent physical examinations were as the control group. Enzyme linked immunosorbent assay （ELISA） was applied to detect serum FGF21 and SCUBE-1 levels. Multivariate Logistic regression was employed to analyze the influencing factors of MACE in MHD patients. The receiver operating characteristic （ROC） curve was used to analyze the predictive values of serum FGF21 and SCUBE-1 in MACEs of MHD patients. Results Serum FGF21 （39.67 ± 5.54） ng/L vs （30.33 ± 3.21） ng/L and SCUBE-1 （33.28 ± 4.41） μg/L vs （25.19 ± 2.68） μg/L in the observation group were significantly higher than those of the control group （P<0.05）. Serum FGF21 （44.94 ± 4.52） ng/L vs （37.55 ± 4.43） ng/L, SCUBE-1 （36.86 ± 3.87） μg/L vs （31.84 ± 3.74） μg/L, history of diabetes （80.85% vs 25.64%） and LDL-C（3.26 ± 0.36） mmol/L vs （2.89 ± 0.30） mmol/L in the occurrence group were significantly higher than those in the non-occurrence group（P<0.05）. FGF21 and SCUBE-1 were influencing factors for the occurrence of MACEs in MHD patients （P<0.05）. The area under the curve （AUC） of serum FGF21 and SCUBE-1 in predicting MACEs was 0.881 and 0.823, respectively, which of their combination for MACE was 0.926. The combination of the two was better than that of the individual prediction （Z combination - FGF21=2.024, Z combination - SCUBE-1=3.082, P=0.043, and 0.002）. Conclusion Serum levels of FGF21 and SCUBE-1 are obviously elevated, which are risk factors for MACEs in MHD patients. The combination of the two has high predictive value for MACE in MHD patients.

       

      • HTML全文
      • 参考文献(23)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回