基于调节性细胞死亡论述肾纤维化的机制研究进展

Research advances Progress in mechanistic studies of renal fibrosis based upon regulatory cell death

摘要: 肾纤维化（renal fibrosis, RF）是多种肾脏疾病进展后期的一种基本病理特征，是导致肾脏功能衰竭的重要原因。RF的表现主要为细胞外基质过度累积，肾组织结构损坏，肾功能不全或者丧失。调节性细胞死亡因涉及多种效应分子参与的信号级联反应，与RF关系密切。本文就调节性细胞死亡参与RF进展的机制进行概述，为临床治疗RF给予参考。

Abstract: As a basic pathological feature at advanced stage of various kidney diseases, renal fibrosis (RF) is an important cause of kidney failure. It is characterized by an excessive accumulation of extracellular matrix (ECM), damage of renal tissue structure and loss of renal function. Regulated cell death (RCD) is closely correlated with RF since it involves a signaling cascade involving effector molecules. This review summarized the mechanism of RCD involved in the progression of RF and provided references for clinical treatment of RF.