Objective  To explore the clinical efficacy of "Yiqing Recipe" for uric acid nephropathy （UAN） through high colonic route and examine its effect on chronic inflammatory state.

Methods  A total of 70 UAN patients were randomized into two groups of control and Yiqing recipe （n = 35 each）. In test group, there were 20 males and 15 females with an age of （57.03 ± 13.05）（28-86） year; In control group, there were 27 males and 8 females with an age of （55.31 ± 12.13）（29-79） year. Control group received a low-purine diet, alkalized urine （sodium bicarbonate tablets）, reduced uric acid （allopurinol or febuxosta）, and reduced blood pressure （except angiotensin converting enzyme inhibitor, ACEI）, angiotensin II receptor antagonist （ARB） and diuretics, control of underlying diseases and other basic treatment plus high colon irrigation and saline enema. Test group received a high retention enema with "Yiqing Recipe" after basic treatment plus high colon lavage. The parameters of blood uric acid （UA）, blood urea nitrogen （BUN）, serum creatinine （Scr）, cystatin C （Cys C）, urinary protein excretion rate （UAER）, 24-hour urinary protein quantitation （24 h-UP）, pain visual analog scale （VAS） score and C-reactive protein （CRP） were recorded.

Results  In test group, UA at pre-treatment and post-treatment was （514.14 ± 78.01） μmol/L vs （396.36 ± 66.66） μmol/L and BUN （6.12 ± 2.43） mmol/L vs （5.35 ± 1.84） mmol/L. In control group, UA at pre-treatment and post-treatment was （496.70 ± 54.43） μmol/L vs （448.78 ± 71.18） μmol/L and BUN （5.54 ± 1.79） mmol/L vs （5.08 ± 1.61） mmol/L. As compared with pre-treatment, UA and BUN decreased in both groups post-treatment （P＜0.01, P＜0.05）. UA was lower in test group than that in control group （396.36 ± 66.66） μmol/L vs （448.78 ± 71.18） μmol/L, P＜0.05 and CRP （2.82 ± 1.56） mg/L vs （3.90 ± 2.72） mg/L, P＜0.05. In control group, CRP showed no obvious change （4.82 ± 5.98） mg/L vs （4.37 ± 2.53） mg/L and UA was significantly higher in test group than that in control group （117.77 ± 75.8） μmol/L vs （47.92 ± 48.17） μmol/L, P＜0.01. As compared with pre-treatment, UAER rose （160.62 ± 62.30） μg/min vs （202.75 ± 75.29） μg/min; （279.34 ± 108.69） μg/min vs （276.34 ± 130.05） μg/min, P＜0.05; 24 h-UP declined （231.30 ± 89.72） mg vs （292.12 ± 108.42） mg; （402.26 ± 156.52） mg vs （397.94 ± 187.26） mg （P＜0.05）; pain VAS scores dropped （1.74 ± 1.36） vs （2.97 ± 1.96）; （4.14 ± 2.49） vs （4.71 ± 2.47）, P＜0.05. And the values of UAER, 24 h-UP and pain VAS were lower in test group than those in control group post-treatment （P＜0.05）. Overall effective rate was higher in test group than that in control group （88.6% vs 65.7%, P＜0.05）.

Conclusion  "Yiqing Recipe" high colonic approach offers a definite cure for UAN. It may relieve the symptoms of joint pain and improve chronic inflammatory state of body.