缺氧诱导因子1α与肾间质纤维化关系的研究进展

Research advances on the relationship between hypoxia-inducible factor-1 α and renal interstitial fibrosis

摘要: 肾间质纤维化（renal interstitial fibrosis，RIF）是各种慢性进展性肾脏病发展为终末期肾病（end stage renal disease，ESRD）的主要病理基础及最终共同途径。缺氧被认为是肾间质纤维化过程中一个重要的微环境因素，而缺氧诱导因子（hypoxia-inducible factor，HIF）是调节氧代谢的关键因子。HIF-1α可以通过诱导细胞周期阻滞、上皮-间充质转化及与经典促纤维化信号通路串扰，从而调节纤维化过程。本文主要对HIF-1α与RIF间的关系及其作用机制进行综述，有助于进一步探讨靶向HIF-1α治疗RIF的可行性。

Abstract: Renal interstitial fibrosis （RIF） is the primary pathological basis and the ultimate common pathway for the progression of various chronic progressive kidney diseases into end-stage renal disease （ESRD）. Hypoxia is regarded as a major microenvironmental factor in the development of renal interstitial fibrosis. And hypoxia-inducible factor （HIF） is a key regulator of oxygen metabolism. HIF-1α regulates fibrotic process through inducing cell cycle arrest, epithelial-mesenchymal transition and crosstalking with classical pro-fibrotic signaling pathways. This review summarized the relationship between HIF-1α and RIF and focused upon its mechanism of action to explore the therapeutic feasibility of targeting HIF-1α for RIF.