单核细胞/高密度脂蛋白胆固醇比值与狼疮肾炎的相关性研究

    Correlation between monocyte/high-density lipoprotein cholesterol ratio and lupus nephritis

      摘要
    • 摘要:
      目的  探讨单核细胞/高密度脂蛋白胆固醇比值（monocytes-to-HDL cholesterol ratio，MHR）与狼疮肾炎（lupus nephritis，LN）的相关性。
      方法  回顾性分析2014年3月至2021年3月在武汉大学中南医院风湿免疫科、肾内科、皮肤科及内分泌科住院的系统性红斑狼疮（systemic lupus erythematosus，SLE）患者的临床资料、实验室检查结果，将患者按SLEDAI评分和肾功能受损程度分组，比较两组患者不同病情程度的临床基本特征并计算MHR，使用多因素Logistic 回归模型分析LN的相关危险因素。
      结果  共纳入患者130例，其中女性123例（96.4%），MHR与血肌酐、患者年龄、24 h尿蛋白定量、SLEDAI 评分呈正相关， 与估算肾小球滤过率、血红蛋白、白蛋白呈负相关（P＜0.05）。多因素logistic 回归分析结果显示，高MHR（OR = 4.522，95%CI: 0.213～2.805，P＜0.05）、低白蛋白（OR = 0.911，95%CI :−0.174～−0.012，P＜0.05）及抗SSA抗体阳性（OR = 4.511，95%CI : 0.414～2.599，P＜0.05）为 SLE 患者肾损伤的独立危险因素。
      结论  MHR与LN密切相关，可作为一个易获得的评估患者病情的炎症指标。

       

      Abstract:
      Objective  To elucidate the relationship between monocyte/high density lipoprotein cholesterol ratio (MHR) and lupus renal damage.
      Methods  Clinical data and laboratory test results were retrospectively reviewed for 130 patients with systemic lupus erythematosus hospitalized at Departments of Rheumatology, Nephrology, Dermatology and Endocrinology between March 2014 and March 2021. They were divided into two groups according to SLEDAI score and degree of renal injury. Clinical characteristics of patients were compared between two groups and MHR was calculated respectively. Multivariate logistic regression model was utilized for examining the risk factors of renal injury in LN patients.
      Results  There were 7 males and 123 females. MHR was correlated positively with serum creatinine, age, 24 h urine protein and SLEDAI score, but negatively with eGFR, Hb and ALB (P＜0.05). Multivariate logistic regression analysis revealed high MHR (OR=4.522, 95%CI: 0.213-2.805, P＜0.05), low ALB (OR=0.911, 95%CI: −0.174- −0.012, P＜0.05) and positive anti-SSA antibody (OR=4.511, 95%CI: 0.414-2.599, P＜0.05) were independent risk factors for renal damage in SLE patients.
      Conclusions  MHR is correlated closely with renal damage in patients. It may be employed as a readily available inflammatory marker for assessing lupus renal damage.

       

      • HTML全文
      • 参考文献(24)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回