成纤维细胞生长因子与缺氧诱导因子在慢性肾脏病血管钙化的研究进展
Research advances of fibroblast growth factor 23 and hypoxia-inducible factor in vascular calcification of chronic kidney disease
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摘要: 目前,流行病学调查显示,慢性肾脏病的发病率逐年上升,越来越多的临床数据表明,血管钙化是慢性肾脏病及终末期肾病病死率的独立预测因子,循环中成纤维细胞生长因子(fibroblast growth factor 23,FGF23)水平升高与血管钙化有着密不可分的关系。目前发现,缺氧诱导因子(hypoxia-inducible factor,HIF)是FGF23在慢性肾脏病血管钙化的新成员,本综述旨在介绍FGF23、HIF与慢性肾脏病血管钙化的关系及目前针对FGF23、HIF引起慢性肾脏病血管钙化的治疗进展。Abstract: Recent epidemiological surveys have demonstrated a rising incidence of chronic kidney disease(CKD) year-by-year.And a growing body of clinical data indicated that vascular calcification is an independent predictor of mortality in chronic kidney disease and end-stage renal disease.A higher level of circulating fibroblast growth factor 23(FGF23) is strongly associated with vascular calcification.Hypoxia-inducible factor(HIF) is a new member of FGF23 in vascular calcification of CKD.This review focused upon the relationship between FGF23 and HIF and vascular calcification and summarized recent therapeutic advances in CKD.
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