毛艳, 杜亮, 张冰斐, 卢丽. 三酰甘油葡萄糖乘积指数、三酰甘油与高密度脂蛋白比值、稳态模型胰岛素抵抗指数、载脂蛋白B与载脂蛋白A1比值、高敏C反应蛋白与高尿酸血症的风险关系[J]. 临床肾脏病杂志, 2022, 22(3): 200-208. DOI: 10.3969/j.issn.1671-2390.2022.03.005
    引用本文: 毛艳, 杜亮, 张冰斐, 卢丽. 三酰甘油葡萄糖乘积指数、三酰甘油与高密度脂蛋白比值、稳态模型胰岛素抵抗指数、载脂蛋白B与载脂蛋白A1比值、高敏C反应蛋白与高尿酸血症的风险关系[J]. 临床肾脏病杂志, 2022, 22(3): 200-208. DOI: 10.3969/j.issn.1671-2390.2022.03.005
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    Mao Yan, Du Liang, Zhang Bing-fei, Lu Li. Relationships of triglyceride-glucose，triglyceride/high-density lipoprotein，homeostasis model assessment-insulin resistance，apolipoprotein B/apolipoprotein A1，high-sensitivity C-reactive protein and risk of hyperuricemia[J]. Journal of Clinical Nephrology, 2022, 22(3): 200-208. DOI: 10.3969/j.issn.1671-2390.2022.03.005
    Citation: Mao Yan, Du Liang, Zhang Bing-fei, Lu Li. Relationships of triglyceride-glucose，triglyceride/high-density lipoprotein，homeostasis model assessment-insulin resistance，apolipoprotein B/apolipoprotein A1，high-sensitivity C-reactive protein and risk of hyperuricemia[J]. Journal of Clinical Nephrology, 2022, 22(3): 200-208. DOI: 10.3969/j.issn.1671-2390.2022.03.005
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    三酰甘油葡萄糖乘积指数、三酰甘油与高密度脂蛋白比值、稳态模型胰岛素抵抗指数、载脂蛋白B与载脂蛋白A1比值、高敏C反应蛋白与高尿酸血症的风险关系

    Relationships of triglyceride-glucose，triglyceride/high-density lipoprotein，homeostasis model assessment-insulin resistance，apolipoprotein B/apolipoprotein A1，high-sensitivity C-reactive protein and risk of hyperuricemia

      摘要
    • 摘要: 目的 分析三酰甘油葡萄糖乘积指数（triglyceride-glucose，TyG）、三酰甘油与高密度脂蛋白比值（triglyceride/high-density lipoprotein，TG/HDL）、稳态模型胰岛素抵抗指数（homeostasis model assessment-insulin resistance，HOMA-IR）、载脂蛋白B与载脂蛋白A1比值（apolipoprotein B/apolipoprotein A1）、高敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）与高尿酸血症（hyperuricemia，HUA）患病的风险关系。方法 选择2009年中国健康和营养状况调查（CHNS）10 241例数据，经合并变量和数据清洗，按照有无HUA划分为两组。采用SPSS22.0和MedCalc 18软件进行统计分析。结果 共纳入9463例研究对象，平均年龄47.53岁，HUA患病1468例（15.5%）。Logistic回归调整协变量后显示，与Q1组相比，Q4组的TyG、TG/HDL、HOMA-IR、ApoB/ApoA1、hs-CRP与HUA的患病风险分别为8.19（5.14~13.04）、7.73（4.95~12.07）、1.94（1.38~2.73）、1.49（1.03~2.16）、2.64（1.80~3.88）。亚组分析显示，男性、年龄≥40岁、体重指数≥24 kg/m2、吸烟饮酒者及合并糖尿病和高血压的人群患HUA的风险更高。受试者工作特征曲线（receiver operating characteristic curve，ROC）分析显示，TyG对HUA预测价值最高，这种趋势集中在男性，年龄≥40岁，体重指数≥24 kg/m2的个体特征。结论 TyG对HUA患病风险和预测能力最高，其次是TG/HDL、hs-CRP、ApoB/ApoA1、HOMA-IR。

       

      Abstract: Objective To explore the relationship between triglyceride-glucose （TG），triglyceride/high-density lipoprotein （TG/HDL），homeostasis model assessment-insulin resistance （HOMA-IR），Apolipoprotein B/Apolipoprotein A1 （ApoB/ApoA1），high-sensitivity C-reactive protein （hs-CRP） and the risk of hyperuricemia （HUA）.Methods Clinical data from 10，241 respondents of 2009 China Health and Nutritional Survey （CHNS） were reviewed.Various variables were merged and cleaned.They were divided into two groups according to the presence or absence of HUA.Software packages SPSS22.0 and MedCalc 18 were utilized for statistical analyses.Results A total of 9463 subjects were included with an average age of 47.53 years and 1468 cases （15.5%） of HUA were identified.After adjusting covariates by Logistic regression，as compared with Q1 group，the risks of TyG，TG/HDL，HOMA-IR，ApoB/ApoA1，hs-CRP and HUA in Q4 group were 8.19（5.14-13.04），7.73（4.95-12.07），1.94（1.38-2.73），1.49（1.03-2.16） and 2.64（1.80-3.88） respectively.Subgroup analyses indicated that males，age≥40 years，body mass index （BMI） ≥24 kg/m2，smokers，alcoholics and people with diabetes mellitus （DM） and hypertension were at higher risk of HUA.Receiver operating characteristic curve （ROC） analyses revealed that TyG had the highest predictive value for HUA.This trend was noteworthy in individuals of males，age≥40 years and BMI≥24 kg/m2.Conclusion TyG offers the highest risk and predictive capability for HUA，followed by TG/HDL，hs-CRP，ApoB/ApoA1 and HOMA-IR.

       

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