Abstract: Objective Toexplore the levels of PLA2R,CD80,suPAR and Gd-IgA in blood and urine specimens of patients with different pathological types of proteinuria kidney disease (PKD) to offer a noninvasive,widely applicable and accurate early diagnostic method.Methods From June 1,2019 to March 31,2020,blood and urine specimens were collected from inpatients or outpatients with PKD and healthy subjects.The relevant biological markers were detected before and after treatment.The changes and significance of blood/urine-related biomarkers were analyzed.Results The urinary level of CD80 was significantly higher than that in other PKDs.It hinted at a possibility of minimal change disease (MCD);The blood level of suPAR was markedly elevated and other biological markers spiked significantly in focal segmental glomerular sclerosis (FSGS);The blood content of PLA2R was elevated in membranous nephropathy (MN) patients and remained much higher than normal control after treatment;Many biological markers in membrane proliferative glomerulonephritis (MPGN) patients were slightly higher than normal control values;The serum level of GD-IgA spiked markedly in IgAN patients.However,PLA2R in urine and CD80 in blood stayed basically normal or were lower than normal control values;Long-term hormone and/or immunosuppressive therapy could not achieve satisfactory outcomes without a precise treatment.Conclusion For five types of PKDs and healthy people,blood/urine-related biomarkers have varying degrees of difference so that accurate treatments may be tailored.