内皮-间充质转分化在腹膜透析相关腹膜纤维化中的研究进展

Research advances of endothelial-mesenchymal transition during peritoneal dialysis-related peritoneal fibrosis

摘要: 腹膜透析是终末期肾脏病患者的肾脏替代治疗之一。腹膜透析相关腹膜纤维化是患者退出腹膜透析最重要的原因。既往研究认为腹膜纤维化的主要机制是上皮-间充质转分化（epithelial-mesenchymal transition，EMT）。近年来，研究发现内皮-间充质转分化（endothelial-mesenchymal transition，EndMT）可能是腹膜纤维化的机制之一，高糖、炎症、氧化应激等均可影响腹膜组织中EndMT的发生发展。因此，本文将综述EndMT在腹膜透析相关腹膜纤维化的研究进展。

Abstract: Peritoneal dialysis is one of renal replacement therapies for patients with end-stage renal disease(ESRD). Peritoneal dialysis-related peritoneal fibrosis is the most important reason for withdrawing peritoneal dialysis in ESRD patients. Previous studies have hinted that a major mechanism of peritoneal fibrosis is epithelial-mesenchymal transition(EMT). Recentstudies have found that endothelial-mesenchymal transition(EndMT) may be one of the mechanisms of peritoneal fibrosis. High glucose, inflammation and oxidative stress affect the occurrence and development of EndMT in peritoneal tissues. This review summarized the latest advances of EndMTduring peritoneal dialysis-related peritoneal fibrosis.