Abstract: With the wide application of endovascular interventional diagnosis and treatment,the incidence of contrast-induced acute kidney injury(CI-AKI)increases sharply,which increases the long-term and short-term mortality and prolongs the duration of hospitalization.Research focusing on the pathogenesis research,prevention and treatment of CI-AKI were closely concerned by clinicians,and relative basic research was totally based on animal model establishment.In this review,the establishment methods and basic mechanism of prevalent and mature animal models of CI-AKI were summarized,in order to provide reference for the basic pathogenesis,drug screening and effectiveness evaluation of contrast-induced acute kidney injury.