Abstract: Objective To investigate whether the expression of serum tumor markers in patients with chronic kidney disease(CKD)has changed,and to analyze the risk factors influencing the changes. Methods The serum tumor markersincluding α-fetoprotein(AFP),carcinoembryonic antigen(CEA),CA125,CA199,CA153,TPSA,albumin(Alb),serum creatinine,hemoglobin levels,age and glomerular filtration rate(GFR)of 427 CKD patients and 420 healthy medical examiners from the Affiliated Hospital of Xuzhou Medical University were collected and compared for differences between the two groups.The relevant factors that lead to changes in tumor markers in patients with CKD were screened out by univariate analysis,and multi-factor logistic regression analysis were used to identify risk factors for elevated tumor indicators. Results There was no significant difference in serum TPSA between the CKD group and the healthy control group(P<0.05).The AFP level was lower than that of the healthy control group,and the difference was statistically significant(P<0.01).The levels of CEA,CA125,CA199,and CA153 were higher than those in the healthy control group,with statistically significantdifferences(P<0.01).Logistic regression analysis showed that decreased glomerular filtration rate was a risk factor for CEA elevation,serum albumin and hemoglobin decline were risk factors for CA125 elevation,serum albumin decrease was a risk factor for CA199 and CA153 elevation,and age was a risk factor for elevated TPSA. Conclusions The application value of TPSA in CKD patients is the same as that in the normal population.In the diagnosis of related tumors based on serum tumor indicators,a comprehensive analysis must be done in conjunction with factors such as patients' age,renal function,serum albumin,and hemoglobin levels.