Abstract: Objective To explore risk factors for catheter-related infection (CRI) of non-cuffed femoral vein catheter in blood purification therapy patients undergoing non-cuffed femoral vein catheterization.Methods The basic information of 252 blood purification therapy patients,treated with double lumen catheter in Hainan Province People's Hospital from April 2015 to February 2017,was analyzed.According to the severity of catheter infection,they were divided into three groups,non-infection group,local infection group (developing bacterial colonization in catheters or catheter opening infection) and catheter-related bloodstream infection group.Univariate analysis and multivariate Logistic regression analysis was performed for the related factors of CRI.Results Among 252 patients,18 cases (7.1%) had catheter-related bloodstream infection (CRBI),10 cases (4%) were catheter-related local infection (CRLI),and 21 cases (8.3%) were catheter bacterial colonization.In univariate analysis,the difference was significant among the three groups in chronic kidney disease stage 5 (CKD 5) and acute renal injury (AKI) proportions (P<0.05);the differences in albumin levels among the three groups were significant (P<0.05);the CRI rate was different in gender,and the CRI rate was higher in males (P<0.05);because of other site infections,the CRI rate of patients who used antibiotics before or during catheterization was lower,and there was significant difference among the three groups in different antibiotic use (P<0.05).Multivariate analysis suggested that male and no antibiotic use during progression were risk factors of CRI (OR=2.22,95%CI 1.086~4.540,P<0.05).Conclusions We can reduce the occurrence of non-cuffed catheter-related infections in the femoral vein,by improving the nutritional status of patients,properly using antibiotics and stressing on catheter cluster management.