Abstract:
Objective To study the relationship between left ventricular hypertrophy(LVH)and Vitamin D 25(OH)D
3 in maintenance dialysis patients.
Methods The clinical and laboratory results of 80 patients with maintenance dialysis were retrospectively analyzed.Meanwhile,Vitamin D levels were detected with radioimmunoassay.The relationships between serum Vitamin D levels and some laboratory parameters were analyzed by using Pearson correlation analysis.The risk factors of left ventricular hypertrophy were investigated through Logistic regression analysis.ROC curve was used to analyze 25(OH)D
3 and predict the optimal cutoff value of LVH.
Results Serum 25(OH)D
3 levels of 80 patients with maintenance hemodialysis were(15.2±3.6)ng/mL.The 25(OH)D
3 levels of the patients in the LVH group were significantly lower than those in the non-LVH group(13.5±2.8)
vs(17.8±3.2)ng/mL,
P<0.05.The 25(OH)D
3 levels exhibited negative correlation with left ventricular end diastolic diameter(LVDd),left ventricular posterior wall thickness(LVPWT),interventricular septum thickness(IVST)and left ventricular mass index(LVMI),and positive correlation with left ventricular ejection fraction(LVEF)(
r=-0.582,
P=0.032;
r=-0.562,
P=0.038;
r=-0.498,
P=0.046;
r=-0.641,
P=0.024;
r=0.726,
P=0.018).Multivariable logistic regression analysis showed that low 25(OH)D
3,C-reaction protein(CRP),total cholesterol(TC),hypertension,anemia were independent risk factors for LVH;ROC curve analysis showed the area under the curve that baseline serum Vitamin D deficiency was used to predict an area under the curve of 0.842,with the optimal cutoff value of 14.28 ng/mL,sensitivity of 68.8% and specificity of 81.2%.
Conclusions The 25(OH)D
3 levels of patients with maintenance hemodialysis decrease significantly,and vitamin D deficiency is an independent factor of LVH in MHD patients.Vitamin D deficiency may be involved in pathogenesis and progression of cardiovascular diseases in hemodialysis patients.
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