何学勤, 周雪丽, 蒋静, 秦敏, 蒲俐, 钟慧. 老年腹膜透析患者甲状旁腺激素水平达标率及其与年龄相关性研究[J]. 临床肾脏病杂志, 2020, 20(2): 142-146. DOI: 10.3969/j.issn.1671-2390.2020.02.010
    引用本文: 何学勤, 周雪丽, 蒋静, 秦敏, 蒲俐, 钟慧. 老年腹膜透析患者甲状旁腺激素水平达标率及其与年龄相关性研究[J]. 临床肾脏病杂志, 2020, 20(2): 142-146. DOI: 10.3969/j.issn.1671-2390.2020.02.010
    HE Xue-qin, ZHOU Xue-li, JIANG Jing, QIN Min, PU Li, ZHONG Hui. A study on standard level compliance rate of parathyroid hormone and its correlation with age in elderly patients with peritoneal dialysis[J]. Journal of Clinical Nephrology, 2020, 20(2): 142-146. DOI: 10.3969/j.issn.1671-2390.2020.02.010
    Citation: HE Xue-qin, ZHOU Xue-li, JIANG Jing, QIN Min, PU Li, ZHONG Hui. A study on standard level compliance rate of parathyroid hormone and its correlation with age in elderly patients with peritoneal dialysis[J]. Journal of Clinical Nephrology, 2020, 20(2): 142-146. DOI: 10.3969/j.issn.1671-2390.2020.02.010

    老年腹膜透析患者甲状旁腺激素水平达标率及其与年龄相关性研究

    A study on standard level compliance rate of parathyroid hormone and its correlation with age in elderly patients with peritoneal dialysis

    • 摘要: 目的 调查分析老年维持性腹膜透析(peritoneal dialysis,PD)患者甲状旁腺激素(parathyroid hormone,PTH)水平达标率及其与年龄的相关性。方法 收集2011年1月至2012年1月期间在四川大学华西医院接受PD治疗3个月以上并规律随访的235例患者的临床资料进行横断面研究,根据年龄分为老年组和非老年组(≥ 65岁和<65岁),比较两组血钙、血磷、PTH及其他生化、营养指标,分析年龄与PTH的相关性。结果 两组性别构成、身高、体质量、透析龄等差异无统计学意义(P>0.05),糖尿病和高血压患病率在老年组患者更高(P>0.05)。老年组PTH达标率低于非老年组(16.66%vs.25.66%),低PTH水平者(<150 pg/mL)老年组高于非老年组(70.83%vs.48.66%)。老年组血磷、血清白蛋白值水平低于非老年组(P<0.05),而血钙及血红蛋白高于非老年组(P<0.05)。相关分析显示年龄与PTH水平呈负相关(r=-0.275,P<0.05)。结论 PD患者PTH水平与年龄相关,老年PD患者PTH水平明显偏低,这可能是老年患者营养状况较差、血磷下降带来的影响。

       

      Abstract: Objective To investigate standard level compliance rate of parathyroid hormone (PTH) and its correlation with age in elderly patients with maintenance peritoneal dialysis (PD). Methods The clinical data of 235 patients, who received PD treatment for more than 3 months and regularly followed up in our hospital from January 2011 to January 2012, were collected for a cross-sectional study. According to age, they were divided into elderly group and non-elderly group(≥ 65 years old and <65 years old).Blood calcium, blood phosphorus, PTH, other biochemical and nutritional indicators of the two groups were compared, and the correlation between age and PTH was analyzed. Results There was no statistically significant difference in gender composition, height, weight and dialysis age between the two groups (P & GT; 0.05 P>0.05). Prevalence of diabetes and hypertension was higher in the elderlygroup (P>0.05). The PTH standard level compliance rate in the elderly group was lower than that in the non-elderly group (16.66% vs. 25.66%). The proportion of patients with lower PTH level (<150 pg/mL) was higher in the elderly group than that in the non-elderly group (70.83% vs. 48.66%). The blood phosphorus and serum albumin levels in the elderly group were lower than those in the non-elderly group (P<0.05), and blood calcium and hemoglobin were higher than the non-elderly group (P<0.05). Correlation analysis showed a negative correlation between age and PTH level(R=-0.275, P<0.05). Conclusions The PTH level is correlated with age in PD patients, and is obviously lower in elderly patients, which might result from poor nutritional status and decreased blood phosphorus in elderly patients.

       

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