Abstract: Objective To investigate the levels of hypersensitivity C-reaction protein (hs-CRP), neutrophil/lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in patients with maintenance hemodialysis (MHD), and to analyze their correlation with cardiac valve calcification, so as to provide valuable information for clinical prediction and diagnosis of cardiac valve calcification. Methods Clinical data of 80 MHD patients undergoing maintenance hemodialysis in our hospital from February 2016 to February 2019 were selected. Patients were divided into two groups according to the presence or absence of the cardiac valve calcification, study group (n=51) and control group (n=29). The study group was further divided into subgroups according to the calcification degree, severe calcification group (n=18), moderate calcification group (n=20) and mild calcification group (n=13). The general data, general biochemical indexes and hs-CRP, NLR and PLR levels between the two groups were compared. The correlation of hs-CRP, NLR and PLR with the severity of calcification was analyzed. The risk factors of cardiac valve calcification were analyzed by multivariate analysis. Results Hs-CRP, NLR and PLR in the study group were higher than those in the control group (P<0.05); The levels of hs-CRP, NLR and PLR were highestin the severe calcification subgroup, followed by the moderate calcification group, and mild calcification group, with statistic difference (P<0.05). Levels of hs-CRP, NLR and PLR were positively correlated with the degree of calcification (P<0.05), and are risk factors for cardiac valve calcification (P<0.05). Conclusions The hs-CRP, NLR and PLR are closely related to the severity of cardiac valve calcification, and early monitoring of the three indices in the course of treatment can reduce the incidence of calcification and improve the quality of life of patients.