Abstract: Objective To explore the clinical effects of hemoperfusion (HP) combined with continuous vena-venous hemofiltration (CVVH) in the treatment of septic shock with acute kidney injury (AKI). Methods The clinical data of 112 patients with septic shock with AKI admitted between January 2016 and December 2018 were retrospectively analyzed. According to the treatment methods, they were divided into observation group (n=52) and control group (n=60). The efficacy indexes of the patients in the two groupsacute physiology and chronic health evaluation (APACHEII), vital signsheart rate (HR), mean arterial pressure (MAP), renal functionserum creatinine (Scr), urea nitrogen (BUN), urine volumeand inflammatory factors indexeshigh-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10), tumor necrosis factor α (TNF-α)were evaluated in the two groups before treatment and after 2 weeks of treatment. Results (1) After 2 weeks of treatment, the APACHE II score, HR and inflammatory factors (hs-CRP, IL-10 and TNF-α) in the two groups were lower than those before treatment (P<0.05) while the MAP values in the two groups was higher than that before treatment (P<0.05), and the changes in the observation group were greater than those in the control group (P<0.05). (2) After 2 weeks of treatment, the Scr, BUN and urine volume in the two groups were higher than those before treatment (P<0.05), and the increases of Scr and BUN in the observation group were smaller than those in the control group (P<0.05), while the increase of urine volume in the observation group was greater than that in the control group (P<0.05). Conclusions Combination between the two blood purification methods of HP and CVVH has better effects in the treatment of septic shock with AKI, and it is beneficial to protect renal function of the patients.