I型血小板反应蛋白7A域及其抗体在特发性膜性肾病中的研究进展

The research progress of thrombospondin type-1 domain 7A and its antibodies in idiopathic membranous nephropathy

摘要: 特发性膜性肾病（idiopathic membranous nephropathy，IMN）是一类病因未明的自身免疫性肾小球疾病。目前研究显示，磷脂酶A2受体（phospholipase A2 receptor，PLA2R）和I型血小板反应蛋白7A域（thrombospondin type-1 domain-containing 7A，THSD7A）与IMN发病之间密切相关。目前血清抗PLA2R抗体检测与肾小球PLA2R抗原染色已可用于临床诊疗与预后判断，但对于THSD7A的相关检测尚未广泛用于临床。因此，本文将对目前THSD7A在IMN中的作用及研究进展作一综述。

Abstract: Idiopathicmembranous nephropathy(IMN) is an autoimmune glomerular disease with unknown etiology. Current studies have shown that phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain 7A (THSD7A) are closely related to the pathogenesis of IMN. At present, serum anti-PLA2R antibody detection and glomerular PLA2R antigen staining have been used for clinical diagnosis and prognosis, but the related detection of THSD7A has not been widely used in clinical practice. Therefore, this paper will review the current role and research progress of THSD7A in IMN.