黄芪注射液对造影剂相关性肾病中性粒细胞明胶酶相关载脂蛋白水平的影响

    Effect of Astragalus injection on neutrophil gelatinase associated lipocalin level in patients with contrast-induced nephropathy

      摘要
    • 摘要: 目的 研究黄芪注射液对造影剂相关性肾病中性粒细胞明胶酶相关载脂蛋白（NGAL）水平的影响。方法 纳入2015年6月至2017年6月在静脉使用造影剂并诊断为造影剂相关性肾病的患者64例，随机分为治疗组和对照组，治疗组给予黄芪注射液20~30 mL，加入生理盐水250 mL静脉滴注，1次/天。对照组给予等量的生理盐水。比较两组患者治疗前以及治疗后24 h，48 h，72 h的血Scr和尿NGAL。结果 治疗组在诊断造影剂相关性肾病后24 h、48 h、72 h的血Scr水平和尿NGAL水平均明显低于对照组。结论 黄芪注射液能显著降低造影剂相关性肾病诊断后24 h、48 h、72 h的血Scr水平和尿NGAL水平，对肾脏具有一定的保护功能。

       

      Abstract: Objective To investigate effect of Astragalus injection on neutrophil gelatinase associated lipocalin(NGAL) level in patients with contrast-induced nephropathy. Methods A total of 64 patients using contrast in the vein and diagnosed with contrast-induced nephropathy from June 2015 to June 2017 were included, and divided into Astragalus group and control group randomly. The patients in the Astragalus group were administered with 20~30 mL Astragalus injection +250 mL physiological saline in a route of intravenous drip, once per day. The patients in the control group were administered with the same amount of physiological saline. Scr and urinary NGAL between the two groups were compared at 24 h, 48 h and 72 h before and after treatment. Results Scr and urinary NGAL levels in the Astragalus group at 24 h, 48 h and 72 h after diagnosis of contrast-induced nephropathy were significantly lower than those in the control group.Conclusions Astragalus injection can significantly reduce Scr and urinary NGAL levels at 24 h, 48 h and 72 h after diagnosis of contrast-induced nephropathy, and protect the kidney.

       

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