Abstract: Objective To evaluate the differences in clinical manifestations and prognosis between the two pathological types of obesity related glomerulopathy (ORG), obesity-associated glomerulopathy (OB-GM) and obesity-related focal segmental glomerulosclerosis (OB-FSGS). Methods The clinical and laboratory data of 18 patients with OB-GM and 16 patients with OB-FSGS diagnosed by renal biopsy from April 1, 2013 to March 31, 2018 were collected and compared. Results Compared with the OB-GM group, the BMI value, the incidence of hypertension and obstructive sleep apnea in the OB-FSGS group were higher (P<0.05). The 24-hour urinary protein quantification and serum creatinine and eGFR levels in the OB-FSGS group were more serious (P<0.05).On the other hand, after weight loss and RAS system inhibitors treatment, the urinary protein decreased significantly (P<0.05), and the renal function recovered in the all ORG patients. Conclusions Compared with the patients with OB-GM, conditions of the patients with OB-FSGS are more complex and serious, but the overall prognosis of ORG is relatively good.