Abstract: Objective To explore and analyze the risk factors of left ventricular hypertrophy (LVH) in patients with non-dialysis chronic kidney disease (ND-CKD), and to provide evidence for prevention of LVH in patients with ND-CKD. Methods The clinical data of 1001 ND-CKD patients who were admitted to the Second Hospital of Shanxi Medical University from January to May 2018 were collected. According to the occurrence of LVH, the patients were divided into LVH group (195 cases) and non-LVH group (806 cases). The clinical data of the two groups were compared. Logistic regression analysis was used to study the risk factors of LVH in ND-CKD patients. The ROC curve was used to study the predictive index of LVH in ND-CKD patients. Results Logistic regression analysis showed systolic blood pressure (OR=1.012), β₂-microglobulin (OR=0.939), total cholesterol (OR=1.183), homocysteine (OR=1.023), B-type natriuretic peptide (BNP) (OR=1.001) and erythrocyte sedimentation rate (OR=1.010) were independent risk factors of LVH in patients with ND-CKD. ROC curve analysis showed that BNP was good indicator for predicting LVH in patients with ND-CKD. Conclusions Early clinical intervention for risk factors of LVH may reduce or delay the onset of LVH and improve the prognosis of patients with CKD.