Abstract: Objective To observe the clinical effect of vitamin D₃ combined with okra capsules treatment on early protein uria patients with diabetic kidney disease(DKD). Methods 120 proteinuria patients with early DKD were randomly divided into treatment group(60 cases) and control groups(60 cases) by blind separation method. The treatment group was given vitamin D₃ intramuscular injection(400 thousand units per time, once per four weeks)combined with okra capsules (2.5 g per time,tid),The control group was only given okra capsules(2.5 g per time,tid).Both groups were treated for 16 weeks. Before and after treatment,the levels of 25-(OH)D₃,UAlb/Cr(UACR),hs-CRP,serum creatinine,blood urea nitrogen and HbA1c were observed. Results After 16 weeks treatment, the levels of UACR,hs-CRP were significantly decreased in two groups after treatment(P<0.05).In treatment group, the concentration of 25-(OH)D₃ (19.0±1.4) ng/ml before treatment was significantly increased to (31.0±4.9) ng/ml after treatment(P<0.05). The levels of blood pressure,SCr and BUN had no significant changes before and after treatment in two groups (P>0.05).In control group, the level of UACR、hs-CRP is (86.8±8.4) mg/g、(0.41±0.11) mg/dl. Intreatment group, the level of UACR、hs-CRP is (52.9±6.8) mg/g、(0.32±0.08) mg/dl. Compared with control group, UACR,hs-CRP were significantly decreased in treatment group (P<0.05). Conclusions Vitamin D₃ combined with okra capsule treatment on proteinuria patients with early DKD is superior to single okra capsule treatment,could effectively reduce early proteinuria and inflammatory reaction, delay the progression of DKD.