Abstract: Objective To explore the quality of life of patients treated with long-term hemodiafiltration. Methods A cross-sectional study was performed on 42 patients with end-stage renal disease who underwent hemodiafiltration for more than 6 months. Blood pressure, hemoglobin, calcium and phosphorus metabolism, parathyroid function, nutritional status, one-yearhospitalization and cardiovascular events were examined in these patients. Results Among the 40 patients, 17 patients (42.5%) had normal blood pressure, 14 patients (35%) had grade 1 hypertension, and systolic blood pressure in 77.5% of patients was <160 mmHg. The mean hemoglobin (Hb) level was (100.9±17.1) g/L, and Hb in 31 patients (77.5%) was ≥ 90 g/L, and that in 12 patients (30%) ≥ 110 g/L. The mean serum calcium (Ca) was (2.37±0.32) mmol/L, and Ca in 16 patients(40%) was 2.1~2.5 mmol/L, and Ca in 16 patients(40%) >2.5 mmol/L. The mean phosphate (P) was(1.70±0.50) mmol/L, and P in 15 patients (37.5%) was 1.13~1.78 mmol/L, and P in 18 patients (45%) >1.78 mmol/L. The mean Ca×P was (48.6±16.6), and Ca×P product in 27 patients was<55. The mean parathyroid hormone (PTH) was (500.9±548.1) ng/L, and iPTH in 5 cases (12.5%) was 150~300 ng/L, and iPTH in 20 cases (50%) >300 ng/L. The mean total protein was (71.4±6.6) g/L, and albumin was (41.6±3.7) g/L. There were no significant differences in levels of Hb, Ca, P, PTH, TP and Alb between elderly patients and non-elderly patients, nor between diabetic patients and non-diabetic patients (P>0.05 for all). One-year cardiovascular event rate was 153.1/1000 patient-years, and one-year hospitalization rate 612.2/1000 patient-years. Conclusions Good nutritional status, pressure controland higher Hb compliance rate were observed in end-stage renal disease patients with long-term hemodiafiltration, but there was severe hypercalcemia, hyperphosphatemia and hyperparathyroidism in these patients. HDF may be more beneficial for elderly patients and diabetic patients.