Abstract: Objective To investigate the influence of high flux hemodialysis (HFHD)on microinflam-matory and nutritional status of uremic patients. Methods 155 cases of uremic patients in our hospital from January 2013 to June 2015 were randomly divided into two groups:82 cases of uremic patients with uremic treated by HFHD were selected into observation group, and 73 cases of uremic patients with uremic treated by hemodiafiltration + hemoperfusion (HDF+HP) in the same period were selected into control group. Before and 12 months after the treatment, blood samples of 155 patients in each group were taken to detect the indicators of hypersensitive C-reactive protein (hs-CRP), interleukin (IL-6), tumor necrosis factor (TNF-α), triglycerides (TC), total cholesterol (TC), β₂-microglobulin (β₂-MG), serum creatinine (SCr), serum phosphorus (Ph), body mass index (BMI), total protein (TP), albumin (Alb), and statistical analyzed. Results After treatment, hs-CRP、IL-6、TNF-α levels of two groups were significantly reduced, statistically difference(P < 0.05), and hs-CRP、IL-6、TNF-α levels of observation group were significantly lower than control group, statistically difference (P < 0.05). After treatment, TG, TC, β₂-MG, SCr, Ph levels of two groups were significantly reduced, statistically difference(P < 0.05), and TG, TC, β₂-MG, Scr, Ph levels of observation group were significantly lower than control group, statistically difference(P < 0.05). After BMI, TP, Alb levels of two groups were significantly increased, statistically difference(P < 0.05), and BMI, TP, Alb levels of observation group were significantly higher than control group, statistically difference(P < 0.05). Conclusions Compared with hemodiafiltration + hemoperfusion (HDF+HP), high flux hemodialysis could effectively improve the microinflammatory, renal function and nutritional status of uremic patients.