Abstract: Objective To analyze the effect of simvastatin on microinflammation in patients with uremia.Methods Randomly The selected 76 patients with chronic renal failure in our hospital from January 2015 to January 2017 were divided into the control group and the observation group. The control group was treated with basic treatment and dialysis. The observation group was treated with simvastatin on the basis of the basic treatment program. The serum levels of inflammatory factors, nutritional indexes, blood lipid, renal function and cardiac function indexes were detected.Results Before the treatment, there was no significant difference between the two groups in IL-6, TNF-α, hs-CRP and Alb contents. After treatment, IL-6, TNF-α, hs-CRP and Alb contents were significantly increased in both two groups as compared with those before treatment, but IL-6, hs-CRP and TNF-α levels were significantly lower, and Alb was significantly higher in the observation group than those in the control group (P<0.05). Before treatment, there was no significant difference in the renal function and blood lipid indexes between two groups. After treatment, the renal function indexes and blood lipid indicators were improved significantly in the two groups as compared with those before treatment. SCr, HDL-C, TG, LDL-C and TC were significantly better in the observation group than those in the control group (P<0.05). Before treatment, there was no significant difference in IVST, LVM and LVMI between two groups (P>0.05). After treatment, IVST, LVM and LVMI indexes in the two groups were decreased, but the decrease was not obvious with the difference being not statistically significant (P>0.05).Conclusions Simvastatin exerts good anti-inflammatory effects, and its combination with basic dialysis for uremia patients could effectively improve the microinflammatorystate of patients, improve renal function and blood lipid indexes, and reduce the incidence of adverse reactions.