Abstract: Objective To analyze the long-term prognosis and influencing factors of renal involvement in Sjögren syndrome (RISS).Methods A total of 104 patients with RISS in Department of Nephrology in our hospital from January 2005 to January 2010 were selected as the research objects, and all wer given immunosuppressive agents. To assess whether doubled blood creatinine as standard can accurately evaluate the long-term prognosis of the patients, good prognosis group and poor prognosis group were set up, and the influencing factors were analyzed.Results During the follow-up period of 2-10 years, the incidence of poor prognosis was 18.27%. Univariate analysis showed that the poor prognosis of RISS was associated with female, serum creatinine, globulin, albumin, serum IgG, chronic renal tubulointerstitial lesions.Multiple Logistic regression revealed that globulin, albumin and serum IgG were the independent risk factors for poor prognosis of RISS.Pearson correlation analysis indicated that globulin, albumin and serum IgG levels were positively correlated with serum creatinine level (P<0.05).ROC curve analysis demonstrated that the optimal cutoff of globulin to predict renal damage was 0.66 g/24h (AUC=0.825, sensitivity 0.826, specificity 0.764), that of albumin was 54.36 g/24h (AUC=0.845, sensitivity 0.816, specificity 0.762), and that of IgG was 34.72 g/L (AUC=0.812, sensitivity 0.806, specificity 0.752).Conclusions The globulin, albumin and serum IgG are positively correlated with the incidence of poor prognosis, suggesting that globulin, albumin and serum IgG are of early assessment value for poor prognosis in RISS.