Abstract: Objective To investigate the effects of different kinds of dialysis on calcium-phosphorus metabolism and inflammatory factors in patients with end-stage renal disease (ESRD).Methods 250 ESRD patients treated in our hospital from January 2015 to December 2015 were divided into two groups given different dialysis procedures: 115 cases given peritoneal dialysis (PD), and the rest 135 cases hemodialysis (HD). All the patients were given a 6-month follow-up investigation. The inflammatory factors (CRP, IL-6, TNF-α) levels, calcium-phosphorus metabolism levels (Ca, P), biochemical index levels total cholesterol (TC), triglyceride (TG), total protein (TP), hemoglobin (Hb), albumin (Alb), serum creatinine (SCr), and blood urea nitrogen (BUN), living quality and incidence of complications between two groups after treatment were compared.Results The C-reactive protein level in PD group was lower than that in HD group (P<0.05). There was no significant difference in IL-6, TNF-α, Ca and P levels between two groups (P>0.05). There was no significant difference in TC, TG, Hb, SCr and BUN between two groups (P>0.05). The TP and Alb in PD group were significantly lower than those in HD group (P<0.05). There was no significant difference in living quality between two groups (P>0.05). The incidence of infection and hypoproteinemia in PD group was significantly higher than that in HD group (P<0.05). The incidence of hypertension, arrhythmia and congestive heart failure in PD group was significantly lower than that in HD group (P<0.05).Conclusions ESRD patients with PD or HD have inflammatory response and patients with HD have more severe response. The effects of two kinds of dialysis on calcium-phosphorus metabolism have no significant difference. The suitable dialysis procedure should be selected in terms of patients' clinical specific conditions.