Abstract: Objective To investigate the relationship between the shear wave velocity (SWV) measured by virtual touch tissue quantification(VTQ) and the stage of early chronic kidney disease (CKD), and to provide SWV reference range of early CKD.Methods One hundred and eighty CKD patients and 100 control subjects without CKD were enrolled in this prospective study from March 2015 to August 2016. SWV was measured by using VTQ inspection of color Doppler ultrasound. CKD patients were divided into 5 groups based on creatinine clearance calculated with MDRD formula. There are 61, 53, 56, 6 and 4 cases in CKD stage 1 to 5, respectively.Results The average SWV value of the study group and control group were (2.20±0.68) m/s and (2.38±0.84) m/s, respectively. There were no significant difference between these two groups(P>0.05).The stage of CKD is negatively related to the SWV vale in trends, but has no significant difference(P>0.05), and each group respectively when compared with the control group had no statistical significance(P>0.05). The combined CKD 1-2 stage and CKD 4-5 stage respectively compared with the control group had no statistical difference(P>0.05). But the combined CKD 3-5 stage respectively compared with the control group. CKD1 stage and CKD 1-2 stage there were significant difference(P<0.05). GFR value comparison between different CKD stage groups have obvious difference(P<0.05).Conclusions The SWV can be detected with VTQ and can be used to evaluate the degree of injury in mid-late stage CKD. The SWV value correlates with the degree of injury in CKD patients negatively(r=-0.422,P=0.032).